| ADAM 17 endopeptidase | |
| Ec Number: | 3.4.24.86 |
| Cas Number: | 151769-16-3 |
ADAM 17 endopeptidase (tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme.[1] This enzyme catalyses the following chemical reaction
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
This enzyme belongs to the peptidase family M12.