ADAMTS9 explained

A disintegrin and metalloproteinase with thrombospondin motifs 9 is an enzyme that in humans is encoded by the ADAMTS9 gene.^{[1] [2]}

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors.

Further reading

• Tang BL . ADAMTS: a novel family of extracellular matrix proteases. . Int. J. Biochem. Cell Biol. . 33 . 1 . 33–44 . 2001 . 11167130 . 10.1016/S1357-2725(00)00061-3 .
• Nagase T, Kikuno R, Ishikawa KI . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 1 . 65–73 . 2000 . 10718198 . 10.1093/dnares/7.1.65 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Somerville RP, Longpre JM, Jungers KA . Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. . J. Biol. Chem. . 278 . 11 . 9503–13 . 2003 . 12514189 . 10.1074/jbc.M211009200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Cross NA, Chandrasekharan S, Jokonya N . The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. . Prostate . 63 . 3 . 269–75 . 2005 . 15599946 . 10.1002/pros.20182 . 24137815 . etal.
• Zeng W, Corcoran C, Collins-Racie LA . Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18. . Biochim. Biophys. Acta . 1760 . 3 . 517–24 . 2006 . 16507336 . 10.1016/j.bbagen.2006.01.013 . etal.
• Koo BH, Longpré JM, Somerville RP . Cell-surface processing of pro-ADAMTS9 by furin. . J. Biol. Chem. . 281 . 18 . 12485–94 . 2006 . 16537537 . 10.1074/jbc.M511083200 . etal. free .
• Lo PH, Leung AC, Kwok CY . Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9. . Oncogene . 26 . 1 . 148–57 . 2007 . 16799631 . 10.1038/sj.onc.1209767 . etal. free .

External links

• The MEROPS online database for peptidases and their inhibitors: M12.021

Notes and References

1. Clark ME, Kelner GS, Turbeville LA, Boyer A, Arden KC, Maki RA . ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family . Genomics . 67 . 3 . 343–50 . Sep 2000. 10936055 . 10.1006/geno.2000.6246 .
2. Web site: Entrez Gene: ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9.