ADAMTS13 endopeptidase explained

ADAMTS13 endopeptidase
Ec Number:3.4.24.87

ADAMTS13 endopeptidase (ADAMTS VWF cleaving metalloprotease, ADAMTS-13, ADAMTS13, vWF-cleaving protease, VWF-CP, vWF-degrading protease, Upshaw factor, von Willebrand factor cleaving protease, ADAMTS13 peptidase) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction

The enzyme cleaves the von Willebrand factor at bond Tyr842-Met843 within the A2 domain

This enzyme belong in the peptidase family M12.

Notes and References

  1. Fujikawa K, Suzuki H, McMullen B, Chung D . Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family . Blood . 98 . 6 . 1662–6 . September 2001 . 11535495 . 10.1182/blood.v98.6.1662 . free .
  2. Larry McIntire . Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, Schade AJ, McIntire LV, Fujikawa K, López JA . ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions . Blood . 100 . 12 . 4033–9 . December 2002 . 12393397 . 10.1182/blood-2002-05-1401 . free .

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