ADAMTS12 explained

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.^[1]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.^[2]

Further reading

• Tang BL . ADAMTS: a novel family of extracellular matrix proteases. . Int. J. Biochem. Cell Biol. . 33 . 1 . 33–44 . 2001 . 11167130 . 10.1016/S1357-2725(00)00061-3 .
• Llamazares M, Obaya AJ, Moncada-Pazos A . The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. . J. Cell Sci. . 120 . Pt 20 . 3544–52 . 2008 . 17895370 . 10.1242/jcs.005751 . etal. free . 10651/42564 . free .
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Liu CJ, Kong W, Xu K . ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein. . J. Biol. Chem. . 281 . 23 . 15800–8 . 2006 . 16611630 . 10.1074/jbc.M513433200 . 1483932 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Dias Neto E, Correa RG, Verjovski-Almeida S . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . 2000PNAS...97.3491D . etal. free .

External links

• The MEROPS online database for peptidases and their inhibitors: M12.237

Notes and References

1. Web site: Entrez Gene: ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12.
2. Web site: Entrez Gene: ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12.