ADAMTS-4 endopeptidase explained

ADAMTS-4 endopeptidase
Ec Number:3.4.24.82
Cas Number:147172-61-0

ADAMTS-4 endopeptidase (aggrecanase-1) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan

This enzyme belongs to the peptidase family M12.

Notes and References

  1. Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD . ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain . The Journal of Biological Chemistry . 277 . 18 . 16059–66 . May 2002 . 11854269 . 10.1074/jbc.M108607200 . free .

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