ADAMDEC1 explained

ADAM-like, decysin 1 is a protein that in humans is encoded by the ADAMDEC1 gene.^[1]

Function

This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during the maturation of dendritic cells. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008].

Further reading

• 9271581. 2199019. 1997. Mueller. C. G.. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. The Journal of Experimental Medicine. 186. 5. 655–63. Rissoan. M. C.. Salinas. B. Ait-Yahia. S. Ravel. O. Bridon. J. M.. Briere. F. Lebecque. S. Liu. Y. J. . 10.1084/jem.186.5.655.
• 12037602. 2002. Bates. E. E.. The ADAMDEC1 (decysin) gene structure: Evolution by duplication in a metalloprotease gene cluster on chromosome 8p12. Immunogenetics. 54. 2. 96–105. Fridman. W. H.. Mueller. C. G.. 10.1007/s00251-002-0430-3. 32863451.
• 14632642. 1783081. 2003. Fritsche. J. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation. Immunology. 110. 4. 450–7. Müller. A. Hausmann. M. Rogler. G. Andreesen. R. Kreutz. M . 10.1111/j.1365-2567.2003.01754.x.
• 19218196. 2684019. 2009. Crouser. E. D.. Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. American Journal of Respiratory and Critical Care Medicine. 179. 10. 929–38. Culver. D. A.. Knox. K. S.. Julian. M. W.. Shao. G. Abraham. S. Liyanarachchi. S. Macre. J. E.. Wewers. M. D.. Gavrilin. M. A.. Ross. P. Abbas. A. Eng. C. 10.1164/rccm.200803-490OC.
• 11673514. 2001. Mueller. C. G.. Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle. Journal of Immunology. 167. 9. 5052–60. Cremer. I. Paulet. P. E.. Niida. S. Maeda. N. Lebeque. S. Fridman. W. H.. Sautès-Fridman. C . 10.4049/jimmunol.167.9.5052. free.
• 18449420. 2008. Berger. M. Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism. Thrombosis and Haemostasis. 99. 5. 905–8. Moscatelli. H. Kulle. B. Luxembourg. B. Blouin. K. Spannagl. M. Lindhoff-Last. E. Schambeck. C. M.. 10.1160/TH08-01-0059. 7494141.

Notes and References

1. Web site: Entrez Gene: ADAM-like, decysin 1. 2014-08-16 .