ADAM33 explained

Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.^{[1] [2]}

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness.^[3] Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[2]

Further reading

• Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, Holloway JW . ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma . Clinical Reviews in Allergy & Immunology . 27 . 1 . 23–34 . August 2004 . 15347848 . 10.1385/CRIAI:27:1:023 . 23971367 .
• Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST . The discovery and role of ADAM33, a new candidate gene for asthma . Expert Reviews in Molecular Medicine . 6 . 17 . 1–12 . August 2004 . 15387895 . 10.1017/S1462399404007963 . 30427584 .
• Holgate ST, Yang Y, Haitchi HM, Powell RM, Holloway JW, Yoshisue H, Pang YY, Cakebread J, Davies DE . The genetics of asthma: ADAM33 as an example of a susceptibility gene . Proceedings of the American Thoracic Society . 3 . 5 . 440–3 . July 2006 . 16799089 . 10.1513/pats.200603-026AW .
• Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, Walsh A, Liu Z, Hayward B, Folz C, Manning SP, Bawa A, Saracino L, Thackston M, Benchekroun Y, Capparell N, Wang M, Adair R, Feng Y, Dubois J, FitzGerald MG, Huang H, Gibson R, Allen KM, Pedan A, Danzig MR, Umland SP, Egan RW, Cuss FM, Rorke S, Clough JB, Holloway JW, Holgate ST, Keith TP . Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness . Nature . 418 . 6896 . 426–30 . July 2002 . 12110844 . 10.1038/nature00878 . 4424215 .
• Garlisi CG, Zou J, Devito KE, Tian F, Zhu FX, Liu J, Shah H, Wan Y, Motasim Billah M, Egan RW, Umland SP . Human ADAM33: protein maturation and localization . Biochemical and Biophysical Research Communications . 301 . 1 . 35–43 . January 2003 . 12535637 . 10.1016/S0006-291X(02)02976-5 .
• Chae SC, Yoon KH, Chung HT . Identification of novel polymorphisms in the Adam33 gene . Journal of Human Genetics . 48 . 5 . 278–81 . 2003 . 12768445 . 10.1007/s10038-003-0019-1 . free .
• Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, Xu J, Bleecker ER, Meyers DA . Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations . The Journal of Allergy and Clinical Immunology . 112 . 4 . 717–22 . October 2003 . 14564349 . 10.1016/s0091-6749(03)01939-0 . free .
• Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V . Crystal structure of the catalytic domain of human ADAM33 . Journal of Molecular Biology . 335 . 1 . 129–37 . January 2004 . 14659745 . 10.1016/j.jmb.2003.10.037 .
• Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, Liu YH, Wang S, Shah H, Wan Y, Umland SP . Catalytic activity of human ADAM33 . The Journal of Biological Chemistry . 279 . 11 . 9818–30 . March 2004 . 14676211 . 10.1074/jbc.M309696200 . free .
• Powell RM, Wicks J, Holloway JW, Holgate ST, Davies DE . The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts . American Journal of Respiratory Cell and Molecular Biology . 31 . 1 . 13–21 . July 2004 . 14742294 . 10.1165/rcmb.2003-0330OC .
• Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, Holgate ST, Davies DE . ADAM33 expression in asthmatic airways and human embryonic lungs . American Journal of Respiratory and Critical Care Medicine . 171 . 9 . 958–65 . May 2005 . 15709049 . 10.1164/rccm.200409-1251OC .
• Zou J, Zhang R, Zhu F, Liu J, Madison V, Umland SP . ADAM33 enzyme properties and substrate specificity . Biochemistry . 44 . 11 . 4247–56 . March 2005 . 15766253 . 10.1021/bi0476230 .
• Simpson A, Maniatis N, Jury F, Cakebread JA, Lowe LA, Holgate ST, Woodcock A, Ollier WE, Collins A, Custovic A, Holloway JW, John SL . Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function . American Journal of Respiratory and Critical Care Medicine . 172 . 1 . 55–60 . July 2005 . 15805180 . 10.1164/rccm.200412-1708OC .

External links

• The MEROPS online database for peptidases and their inhibitors: M12.244

Notes and References

1. Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, Yoshino K, Ishiguro H, Higashiyama S . Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity . Gene . 282 . 1–2 . 227–36 . January 2002 . 11814695 . 10.1016/S0378-1119(01)00818-6 .
2. Web site: Entrez Gene: ADAM33 ADAM metallopeptidase domain 33.
3. Davies. Elizabeth R.. Kelly. Joanne F.C.. Howarth. Peter H.. Wilson. David I.. Holgate. Stephen T.. Davies. Donna E.. Whitsett. Jeffrey A.. Haitchi. Hans Michael . 2016-07-21. Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life. JCI Insight. en. 1. 11. 10.1172/jci.insight.87632. 0021-9738. 27489884. 4968941.