ADAM23 explained

Disintegrin and metalloproteinase domain-containing protein 23 is a non-catalytic protein that in humans is encoded by the ADAM23 gene.^{[1] [2]} It is a member of the ADAM family of extracellular matrix metalloproteinases.

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.^[2]

Further reading

• Roberts CM, Tani PH, Bridges LC, Laszik Z, Bowditch RD . MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes . The Journal of Biological Chemistry . 274 . 41 . 29251–9 . Oct 1999 . 10506182 . 10.1074/jbc.274.41.29251 . free .
• Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP . The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries . Gene . 237 . 1 . 61–70 . Sep 1999 . 10524237 . 10.1016/S0378-1119(99)00302-9 .
• Cal S, Freije JM, López JM, Takada Y, López-Otín C . ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism . Molecular Biology of the Cell . 11 . 4 . 1457–69 . Apr 2000 . 10749942 . 14859 . 10.1091/mbc.11.4.1457 .
• Sun YP, Deng KJ, Wang F, Zhang J, Huang X, Qiao S, Zhao S . Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains . Gene . 325 . 171–8 . Jan 2004 . 14697522 . 10.1016/j.gene.2003.10.012 .
• Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA . Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues . Nature Biotechnology . 22 . 6 . 724–31 . Jun 2004 . 15146195 . 10.1038/nbt969 . 36630738 .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–16 . Jun 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Costa FF, Colin C, Shinjo SM, Zanata SM, Marie SK, Sogayar MC, Camargo AA . ADAM23 methylation and expression analysis in brain tumors . Neuroscience Letters . 380 . 3 . 260–4 . Jun 2005 . 15862898 . 10.1016/j.neulet.2005.01.050 . 42504882 .
• Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R . Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry . Nature Methods . 2 . 8 . 591–8 . Aug 2005 . 16094384 . 10.1038/nmeth776 . 20475874 .
• Takada H, Imoto I, Tsuda H, Nakanishi Y, Ichikura T, Mochizuki H, Mitsufuji S, Hosoda F, Hirohashi S, Ohki M, Inazawa J . ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation . Oncogene . 24 . 54 . 8051–60 . Dec 2005 . 16103878 . 10.1038/sj.onc.1208952 . free .

External links

• The MEROPS online database for peptidases and their inhibitors: M12.979

Notes and References

1. Sagane K, Ohya Y, Hasegawa Y, Tanaka I . Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain . The Biochemical Journal . 334 (Pt 1) . Pt 1 . 93–8 . Aug 1998 . 9693107 . 1219666 . 10.1042/bj3340093.
2. Web site: Entrez Gene: ADAM23 ADAM metallopeptidase domain 23.