ADAM22 explained

Disintegrin and metalloproteinase domain-containing protein 22, also known as ADAM22, is an enzyme that in humans is encoded by the ADAM22 gene.[1] [2] [3]

Function

ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript variants.[3]

Interactions

ADAM22 has been shown to interact with DLG4.[4]

Further reading

External links

Notes and References

  1. Sagane K, Ohya Y, Hasegawa Y, Tanaka I . Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain . The Biochemical Journal . 334 (Pt 1) . Pt 1 . 93–8 . August 1998 . 9693107 . 1219666 . 10.1042/bj3340093.
  2. Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP . The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries . Gene . 237 . 1 . 61–70 . September 1999 . 10524237 . 10.1016/S0378-1119(99)00302-9 .
  3. Web site: Entrez Gene: ADAM22 ADAM metallopeptidase domain 22.
  4. Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M . Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission . Science . 313 . 5794 . 1792–5 . September 2006 . 16990550 . 10.1126/science.1129947 . 2006Sci...313.1792F . 33024022 .