ADAM2 explained

Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin^[1] is an enzyme that in humans is encoded by the ADAM2 gene.^{[2] [3] [4]}

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.^[4] The other subunit is ADAM1 or alpha-fertilin.^[1]

Further reading

• Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y . Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions . The Journal of Biological Chemistry . 277 . 20 . 17804–10 . May 2002 . 11882657 . 10.1074/jbc.M200086200 . free .
• Ikawa M, Nakanishi T, Yamada S, Wada I, Kominami K, Tanaka H, Nozaki M, Nishimune Y, Okabe M . Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility . Developmental Biology . 240 . 1 . 254–61 . December 2001 . 11784061 . 10.1006/dbio.2001.0462 . free .
• Cho C, Ge H, Branciforte D, Primakoff P, Myles DG . Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion . Developmental Biology . 222 . 2 . 289–95 . June 2000 . 10837118 . 10.1006/dbio.2000.9703 . free .
• Chen MS, Tung KS, Coonrod SA, Takahashi Y, Bigler D, Chang A, Yamashita Y, Kincade PW, Herr JC, White JM . Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization . Proceedings of the National Academy of Sciences of the United States of America . 96 . 21 . 11830–5 . October 1999 . 10518536 . 18372 . 10.1073/pnas.96.21.11830 . 1999PNAS...9611830C . free .
• Chen H, Sampson NS . Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta . Chemistry & Biology . 6 . 1 . 1–10 . January 1999 . 9889149 . 10.1016/S1074-5521(99)80015-5 . free .
• Vidaeus CM, von Kapp-Herr C, Golden WL, Eddy RL, Shows TB, Herr JC . Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member . Molecular Reproduction and Development . 46 . 3 . 363–9 . March 1997 . 9041139 . 10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-# . 196584546 .
• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin . The Journal of Infection . 24 . 3 . 317–20 . May 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .

External links

• The MEROPS online database for peptidases and their inhibitors: M12.950

Notes and References

1. Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E . Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation . Reproductive Biology and Endocrinology . 9 . 96 . June 2011 . 21718510 . 10.1186/1477-7827-9-96 . 3141649 . free .
2. Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF . Molecular cloning of the human fertilin beta subunit . Biochemical and Biophysical Research Communications . 224 . 2 . 318–26 . July 1996 . 8702389 . 10.1006/bbrc.1996.1027 .
3. Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA . Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB) . Genomics . 40 . 1 . 190–2 . February 1997 . 9070941 . 10.1006/geno.1996.4531 .
4. Web site: Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta).