ADAM19 explained
ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene.[1]
Function
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.[1]
Interactions
ADAM19 has been shown to interact with ABI2.[2]
Further reading
- Adams MD, Kerlavage AR, Fields C, Venter JC . 3,400 new expressed sequence tags identify diversity of transcripts in human brain . Nature Genetics . 4 . 3 . 256–67 . Jul 1993 . 8358434 . 10.1038/ng0793-256 . 20528590 .
- Inoue D, Reid M, Lum L, Krätzschmar J, Weskamp G, Myung YM, Baron R, Blobel CP . Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells . The Journal of Biological Chemistry . 273 . 7 . 4180–7 . Feb 1998 . 9461614 . 10.1074/jbc.273.7.4180 . free .
- Hirohata S, Seldin MF, Apte SS . Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11 . Genomics . 54 . 1 . 178–9 . Nov 1998 . 9806848 . 10.1006/geno.1998.5544 .
- Fritsche J, Moser M, Faust S, Peuker A, Büttner R, Andreesen R, Kreutz M . Molecular cloning and characterization of a human metalloprotease disintegrin--a novel marker for dendritic cell differentiation . Blood . 96 . 2 . 732–9 . Jul 2000 . 10887142 . 10.1182/blood.V96.2.732.
- Shirakabe K, Wakatsuki S, Kurisaki T, Fujisawa-Sehara A . Roles of Meltrin beta /ADAM19 in the processing of neuregulin . The Journal of Biological Chemistry . 276 . 12 . 9352–8 . Mar 2001 . 11116142 . 10.1074/jbc.M007913200 . free .
- Wei P, Zhao YG, Zhuang L, Ruben S, Sang QX . Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta . Biochemical and Biophysical Research Communications . 280 . 3 . 744–55 . Jan 2001 . 11162584 . 10.1006/bbrc.2000.4200 .
- Zhao YG, Wei P, Sang QX . Inhibitory antibodies against endopeptidase activity of human adamalysin 19 . Biochemical and Biophysical Research Communications . 289 . 1 . 288–94 . Nov 2001 . 11708814 . 10.1006/bbrc.2001.5958 .
- Kang T, Zhao YG, Pei D, Sucic JF, Sang QX . Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites . The Journal of Biological Chemistry . 277 . 28 . 25583–91 . Jul 2002 . 12006600 . 10.1074/jbc.M203532200 . free .
- Díaz-Rodríguez E, Montero JC, Esparís-Ogando A, Yuste L, Pandiella A . Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding . Molecular Biology of the Cell . 13 . 6 . 2031–44 . Jun 2002 . 12058067 . 117622 . 10.1091/mbc.01-11-0561 .
- Kang T, Park HI, Suh Y, Zhao YG, Tschesche H, Sang QX . Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity . The Journal of Biological Chemistry . 277 . 50 . 48514–22 . Dec 2002 . 12393862 . 10.1074/jbc.M208961200 . free .
- Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C . Screen and identification of proteins interacting with ADAM19 cytoplasmic tail . Molecular Biology Reports . 29 . 3 . 317–23 . Sep 2002 . 12463424 . 10.1023/A:1020409217215 . 22611084 .
- Abram CL, Seals DF, Pass I, Salinsky D, Maurer L, Roth TM, Courtneidge SA . The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells . The Journal of Biological Chemistry . 278 . 19 . 16844–51 . May 2003 . 12615925 . 10.1074/jbc.M300267200 . free .
- Chesneau V, Becherer JD, Zheng Y, Erdjument-Bromage H, Tempst P, Blobel CP . Catalytic properties of ADAM19 . The Journal of Biological Chemistry . 278 . 25 . 22331–40 . Jun 2003 . 12682046 . 10.1074/jbc.M302781200 . free .
- Kang T, Tschesche H, Amy Sang QX . Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19 . Experimental Cell Research . 298 . 1 . 285–95 . Aug 2004 . 15242783 . 10.1016/j.yexcr.2004.04.022 .
- Ehrnsperger A, Rehli M, Thu-Hang P, Kreutz M . Epigenetic regulation of the dendritic cell-marker gene ADAM19 . Biochemical and Biophysical Research Communications . 332 . 2 . 456–64 . Jul 2005 . 15896713 . 10.1016/j.bbrc.2005.04.149 .
- Melenhorst WB, van den Heuvel MC, Stegeman CA, van der Leij J, Huitema S, van den Berg A, van Goor H . Upregulation of ADAM19 in chronic allograft nephropathy . American Journal of Transplantation . 6 . 7 . 1673–81 . Jul 2006 . 16827870 . 10.1111/j.1600-6143.2006.01384.x . 24891674 . free .
- Tanabe C, Hotoda N, Sasagawa N, Sehara-Fujisawa A, Maruyama K, Ishiura S . ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells . Biochemical and Biophysical Research Communications . 352 . 1 . 111–7 . Jan 2007 . 17112471 . 10.1016/j.bbrc.2006.10.181 .
Notes and References
- Web site: Entrez Gene: ADAM19 ADAM metallopeptidase domain 19 (meltrin beta).
- Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C . Screen and identification of proteins interacting with ADAM19 cytoplasmic tail . Molecular Biology Reports . 29 . 3 . 317–23 . Sep 2002 . 12463424 . 10.1023/A:1020409217215 . 22611084 .