ADAM18 explained

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.^{[1] [2]}

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.^[2]

Further reading

• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Zhu GZ, Lin Y, Myles DG, Primakoff P . Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization. . Gene . 234 . 2 . 227–37 . 1999 . 10395895 . 10.1016/S0378-1119(99)00208-5 .
• Frayne J, Jury JA, Barker HL . Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract. . Mol. Hum. Reprod. . 4 . 5 . 429–37 . 1998 . 9665629 . 10.1093/molehr/4.5.429 . etal. free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

External links

• The MEROPS online database for peptidases and their inhibitors: M12.957

Notes and References

1. Frayne J, Hurd EA, Hall L . Human tMDC III: a sperm protein with a potential role in oocyte recognition . Mol Hum Reprod . 8 . 9 . 817–22 . Aug 2002. 12200459 . 10.1093/molehr/8.9.817 . free .
2. Web site: Entrez Gene: ADAM18 ADAM metallopeptidase domain 18.