ADAM11 explained

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.^{[1] [2]}

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.^[2]

Further reading

• Wolfsberg TG, Primakoff P, Myles DG, White JM . ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell- matrix interactions . J. Cell Biol. . 131 . 2 . 275–8 . 1995 . 7593158 . 10.1083/jcb.131.2.275 . 2199973 .
• Katagiri T, Harada Y, Emi M, Nakamura Y . Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing . Cytogenet. Cell Genet. . 68 . 1–2 . 39–44 . 1994 . 7956356 . 10.1159/000133884 .
• Sagane K, Ohya Y, Hasegawa Y, Tanaka I . Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain . Biochem. J. . 334 (Pt 1) . Pt 1. 93–8 . 1998 . 9693107 . 10.1042/bj3340093. 1219666 .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Hillman RT, Green RE, Brenner SE . An unappreciated role for RNA surveillance . Genome Biol. . 5 . 2 . R8 . 2005 . 14759258 . 10.1186/gb-2004-5-2-r8 . 395752 . free .
• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 . etal.
• Fu GK, Wang JT, Yang J . Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes . Genomics . 84 . 1 . 205–10 . 2005 . 15203218 . 10.1016/j.ygeno.2004.01.011 . etal.

External links

• The MEROPS online database for peptidases and their inhibitors: M12.976

Notes and References

1. Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y . A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers . Nat Genet . 5 . 2 . 151–7 . Jan 1994. 8252040 . 10.1038/ng1093-151 . 11770397 .
2. Web site: Entrez Gene: ADAM11 ADAM metallopeptidase domain 11.