ACVR1C explained

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.^[1] ACVR1C is a type I receptor for the TGFB family of signaling molecules.^[1]

ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.^[2]

Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.^[1]

References

Further reading

• Carlsson LM, Jacobson P, Walley A . ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease . Biochem. Biophys. Res. Commun. . 382 . 2 . 309–14 . 2009 . 19275893 . 10.1016/j.bbrc.2009.03.014 . 2681012 . etal.
• Reissmann E, Jörnvall H, Blokzijl A . The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development . Genes Dev. . 15 . 15 . 2010–22 . 2001 . 11485994 . 10.1101/gad.201801 . 312747 . etal.
• Andersson O, Korach-Andre M, Reissmann E . Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity . Proc. Natl. Acad. Sci. U.S.A. . 105 . 20 . 7252–6 . 2008 . 18480259 . 10.1073/pnas.0800272105 . 2438236 . 2008PNAS..105.7252A . etal. free .
• Watanabe R, Shen ZP, Tsuda K, Yamada Y . Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells . Biochem. Biophys. Res. Commun. . 377 . 3 . 867–72 . 2008 . 18951876 . 10.1016/j.bbrc.2008.10.074 .
• Roberts HJ, Hu S, Qiu Q . Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta . Biol. Reprod. . 68 . 5 . 1719–26 . 2003 . 12606401 . 10.1095/biolreprod.102.013045 . etal. free .
• Hillier LW, Graves TA, Fulton RS . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Xu G, Zhong Y, Munir S . Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7 . J. Clin. Endocrinol. Metab. . 89 . 11 . 5523–34 . 2004 . 15531507 . 10.1210/jc.2004-0893 . etal. free .
• Xu G, Bernaudo S, Fu G . Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7 . Mol. Biol. Cell . 19 . 11 . 4968–79 . 2008 . 18784254 . 10.1091/mbc.E08-03-0259 . 2575152 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Kim BC, van Gelder H, Kim TA . Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells . J. Biol. Chem. . 279 . 27 . 28458–65 . 2004 . 15107418 . 10.1074/jbc.M313277200 . 29027775 . etal. free .
• Munir S, Xu G, Wu Y . Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells . J. Biol. Chem. . 279 . 30 . 31277–86 . 2004 . 15150278 . 10.1074/jbc.M400641200 . etal. free .
• Xu G, Zhou H, Wang Q . Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines . Mol. Cancer Res. . 4 . 4 . 235–46 . 2006 . 16603637 . 10.1158/1541-7786.MCR-05-0174 . etal. free .
• Tsuchida K, Nakatani M, Yamakawa N . Activin isoforms signal through type I receptor serine/threonine kinase ALK7 . Mol. Cell. Endocrinol. . 220 . 1–2 . 59–65 . 2004 . 15196700 . 10.1016/j.mce.2004.03.009 . 25170545 . etal.

Notes and References

1. Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O . cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C) . Cytogenet. Cell Genet. . 95 . 3–4 . 157–62 . 2001 . 12063393 . 10.1159/000059339. 30962803 .
2. Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS . SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 . Mol. Pharmacol. . 62 . 1 . 65–74 . July 2002 . 12065756 . 10.1124/mol.62.1.65. 15185199 .