ACT Biotech Inc explained

ACT Biotech Inc is a San Francisco-based, privately held biopharmaceutical company focused on the development and commercialization of targeted cancer drugs.^{[1] [2]} It was founded in 2008.^[3]

The Company's clinical stage pipeline includes:

• Telatinib, an oral kinase inhibitor for the first-line treatment of advanced gastric cancer. It has been granted Orphan Drug status by the U.S. Food and Drug Administration (FDA).^[4] It has reported encouraging interim results from a phase II trial.^[1]
• ACTB1003, an oral kinase inhibitor that targets cancer cells through multiple modes of action. It inhibits cancer cell growth by targeting the FGF receptor family, which are mutated in a number of human cancer types. ACTB1003 also directly induces apoptosis by targeting kinases downstream of the PI3K pathway, all at low nanomolar concentrations.

Other pipeline products include an oral Aurora A and B kinase inhibitor at the pre-IND stage, and an ABL tyrosine kinase inhibitor targeting the T315I mutant enzyme in pre-clinical development.^{[5] [6]}

External links

• actbiotech.com

Notes and References

1. News: ACT BIOTECH Announces Positive Interim Phase 2 Results with Telatinib in First-line Gastric Cancer . 11 Oct 2010 .
2. News: ACT Biotech Acquires Clinical and Early Stage Oncology Portfolio Licenses From Bayer Healthcare . 7 May 2008 . 23 January 2018 . https://web.archive.org/web/20161025184311/https://www.drugs.com/news/act-biotech-acquires-clinical-early-stage-oncology-portfolio-licenses-bayer-healthcare-8165.html . 25 October 2016 . dead .
3. News: ACT Biotech co-founder Ali Fattaey makes tracks to Curis . Leuty . Ron . . February 19, 2013 . October 24, 2016.
4. News: ACT Biotech Receives Orphan Drug Designation for Telatinib, an Orally Available and Highly Selective Kinase Inhibitor, in . 2 June 2010 .
5. News: ACT Biotech Inc.. 1 April 2011. Jim Kling. Medtech Insight. 22 February 2023.
6. Web site: biotickr . 2022-10-23 . biotickr.