ACTR3B explained

Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene.^[1] Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.^[1]

Function

This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility.^[1]

Further reading

• Machesky LM, Gould KL . The Arp2/3 complex: a multifunctional actin organizer . Current Opinion in Cell Biology . 11 . 1 . 117–21 . Feb 1999 . 10047519 . 10.1016/S0955-0674(99)80014-3 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Shindo-Okada N, Iigo M . Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells . Biochemical and Biophysical Research Communications . 312 . 4 . 889–96 . Dec 2003 . 14651955 . 10.1016/j.bbrc.2003.10.200 .
• Shindo-Okada N, Shimizu K . Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma . Biochemical and Biophysical Research Communications . 280 . 1 . 61–7 . Jan 2001 . 11162478 . 10.1006/bbrc.2000.4059 .
• Jay P, Bergé-Lefranc JL, Massacrier A, Roessler E, Wallis D, Muenke M, Gastaldi M, Taviaux S, Cau P, Berta P . ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells . European Journal of Biochemistry . 267 . 10 . 2921–8 . May 2000 . 10806390 . 10.1046/j.1432-1327.2000.01306.x . free .

Notes and References

1. Web site: Entrez Gene: ACTR3B ARP3 actin-related protein 3 homolog B (yeast).