ACTR1B explained

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.^{[1] [2] [3]}

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.^[3]

Further reading

• Hillier LW, Graves TA, Fulton RS . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Eckley DM, Schroer TA . Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1 . Mol. Biol. Cell . 14 . 7 . 2645–54 . 2004 . 12857853 . 10.1091/mbc.E03-01-0049 . 165665 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Simpson JC, Wellenreuther R, Poustka A . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 . etal.
• Adams MD, Dubnick M, Kerlavage AR . Sequence identification of 2,375 human brain genes . Nature . 355 . 6361 . 632–4 . 1992 . 1538749 . 10.1038/355632a0 . 1992Natur.355..632A . 4234345 . etal.

Notes and References

1. Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI . Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins . Mol Biol Cell . 5 . 12 . 1301–10 . May 1995 . 7696711 . 301159 . 10.1091/mbc.5.12.1301.
2. Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI . Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization . Cytogenet Cell Genet . 84 . 1–2 . 48–9 . Jun 1999 . 10343100 . 10.1159/000015211 . 83665096 .
3. Web site: Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast).