ACTL6B explained

Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.^[2]

Interactions

ACTL6B has been shown to interact with CTBP1.^[3]

Further reading

• Schafer DA, Schroer TA . Actin-related proteins . Annu. Rev. Cell Dev. Biol. . 15 . 341–363 . 2000 . 10611965 . 10.1146/annurev.cellbio.15.1.341.
• Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097 . Sanger Centre . The . Washington University Genome Sequencing Cente . The . free.
• Harata M, Mochizuki R, Mizuno S . Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues . Biosci. Biotechnol. Biochem. . 63 . 5 . 917–923 . 1999 . 10380635 . 10.1271/bbb.63.917. free .
• Olave I, Wang W, Xue Y, Kuo A, Crabtree GR . Identification of a polymorphic, neuron-specific chromatin remodeling complex . Genes Dev. . 16 . 19 . 2509–2517 . 2002 . 12368262 . 187451 . 10.1101/gad.992102.
• Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M . Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex . Biochem. Biophys. Res. Commun. . 299 . 2 . 328–334 . 2003 . 12437990 . 10.1016/S0006-291X(02)02637-2.
• Oma Y, Nishimori K, Harata M . The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP . Biochem. Biophys. Res. Commun. . 301 . 2 . 521–528 . 2003 . 12565893 . 10.1016/S0006-291X(02)03073-5.

Notes and References

1. Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A . Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes . Genome Res . 8 . 10 . 1060–73 . December 1998 . 9799793 . 310788 . 10.1101/gr.8.10.1060.
2. Web site: Entrez Gene: ACTL6B actin-like 6B .
3. Oma Y, Nishimori K, Harata M . The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP . Biochem. Biophys. Res. Commun. . 301 . 2 . 521–528 . February 2003 . 12565893 . 10.1016/S0006-291X(02)03073-5.