ACT-335827 explained

ACT-335827 is an orally available, selective orexin 1 receptor antagonist with anxiolytic effects in animals. Unlike other orexin receptor antagonists, ACT-335827 lacks sedative effects and was found to have no impact on sleep architecture in mice.[1] [2]

Notes and References

  1. Steiner MA, Gatfield J, Brisbare-Roch C, Dietrich H, Treiber A, Jenck F, Boss C . Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist . ChemMedChem . 8 . 6 . 898–903 . June 2013 . 23589487 . 10.1002/cmdc.201300003 . 21644009 .
  2. Merlo Pich E, Melotto S . Orexin 1 receptor antagonists in compulsive behavior and anxiety: possible therapeutic use . Frontiers in Neuroscience . 8 . 26 . 2014 . 24592206 . 10.3389/fnins.2014.00026 . 3923148 . free .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ACT-335827".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.