ACSS3 explained

Acyl-CoA synthetase short-chain family member 3 is a protein that in humans is encoded by the ACSS3 gene.^[1]

Function

ACSS3 is part of a family known as Acyl-coenzyme A synthetases (ACSs), which catalyze the initial reaction in fatty acid metabolism. This reaction activates fatty acids via thioesterification to CoA, thereby allowing their participation in both anabolic and catabolic pathways. The existence of many ACSs suggests that each plays a unique role, directing the acyl-CoA product to a specific metabolic fate. Knowing the full complement of ACS genes in the human genome will facilitate future studies to characterize their specific biological functions.^[2]

Further reading

• Hunter AM, Leuchter AF, Power RA, Muthén B, McGrath PJ, Lewis CM, Cook IA, Garriock HA, McGuffin P, Uher R, Hamilton SP . A genome-wide association study of a sustained pattern of antidepressant response . Journal of Psychiatric Research . 47 . 9 . 1157–65 . Sep 2013 . 23726668 . 3710535 . 10.1016/j.jpsychires.2013.05.002 .
• Watkins PA, Maiguel D, Jia Z, Pevsner J . Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome . Journal of Lipid Research . 48 . 12 . 2736–50 . Dec 2007 . 17762044 . 10.1194/jlr.M700378-JLR200 . free .

Notes and References

1. Web site: Entrez Gene: Acyl-CoA synthetase short-chain family member 3 .
2. Watkins PA, Maiguel D, Jia Z, Pevsner J . Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome . Journal of Lipid Research . 48 . 12 . 2736–50 . Dec 2007 . 17762044 . 10.1194/jlr.M700378-JLR200 . free .