ACSL6 explained

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene.^{[1] [2] [3]} Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA.^[2]

Structure

The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1. The gene contains 23 exons. ACSL6 encodes a 77.7 kDa protein that is composed of 697 amino acids; 10 peptides have been observed through mass spectrometry data.^[4]

Further reading

• Soupene E, Kuypers FA . Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains . BMC Mol. Biol. . 7. 21 . 2006 . 16834775 . 1543647 . 10.1186/1471-2199-7-21 . free .
• Kang H, Lee SK, Kim MH . Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure . Fertil. Steril. . 91 . 4 Suppl . 1339–43 . 2009 . 18555221 . 10.1016/j.fertnstert.2008.03.035 . etal. free .
• Nagase T, Ishikawa K, Suyama M . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 6 . 355–64 . 1998 . 10048485 . 10.1093/dnares/5.6.355. etal. free .
• Ma J, Dempsey AA, Stamatiou D . Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects . Atherosclerosis . 191 . 1 . 63–72 . 2007 . 16806233 . 10.1016/j.atherosclerosis.2006.05.032 . etal.
• Mashek DG, Bornfeldt KE, Coleman RA . Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family . J. Lipid Res. . 45 . 10 . 1958–61 . 2004 . 15292367 . 10.1194/jlr.E400002-JLR200 . etal. free .
• Murati A, Adélaïde J, Gelsi-Boyer V . t(5;12)(q23-31;p13) with ETV6-ACSL6 gene fusion in polycythemia vera . Leukemia . 20 . 6 . 1175–8 . 2006 . 16572202 . 10.1038/sj.leu.2404194 . etal. free .
• Luo XJ, Diao HB, Wang JK . Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese . J. Med. Genet. . 45 . 12 . 818–26 . 2008 . 18718982 . 10.1136/jmg.2008.060657 . 206999081 . etal.
• Chen X, Wang X, Hossain S . Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia . Hum. Mol. Genet. . 15 . 22 . 3329–42 . 2006 . 17030554 . 10.1093/hmg/ddl409 . etal. free .
• Denoeud F, Kapranov P, Ucla C . Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions . Genome Res. . 17 . 6 . 746–59 . 2007 . 17567994 . 1891335 . 10.1101/gr.5660607 . etal.
• Edwards TL, Wang X, Chen Q . Interaction between Interleukin 3 and Dystrobrevin-Binding Protein 1 in Schizophrenia . Schizophr. Res. . 106 . 2–3 . 208–17 . 2008 . 18804346 . 2746913 . 10.1016/j.schres.2008.07.022 . etal.
• Chowdari KV, Northup A, Pless L . DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia . Genes Brain Behav. . 6 . 3 . 229–39 . 2007 . 16827919 . 10.1111/j.1601-183X.2006.00251.x . 44288193 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Wang L, McDonnell SK, Hebbring SJ . Polymorphisms in mitochondrial genes and prostate cancer risk . Cancer Epidemiol. Biomarkers Prev. . 17 . 12 . 3558–66 . 2008 . 19064571 . 2750891 . 10.1158/1055-9965.EPI-08-0434 . etal.

Notes and References

1. Web site: Entrez Gene: acyl-CoA synthetase long-chain family member 6.
2. Malhotra KT, Malhotra K, Lubin BH, Kuypers FA . Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors . Biochem. J. . 344 Pt 1 . Pt 1. 135–43 . November 1999 . 10548543 . 1220623 . 10.1042/0264-6021:3440135.
3. Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K . Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13) . Genes Chromosomes Cancer . 26 . 3 . 192–202 . November 1999 . 10502316 . 10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E. free .
4. Web site: Long-chain-fatty-acid--CoA ligase 6 . Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) .