ACSBG1 explained

Acyl-CoA Synthetase, Bubblegum Family, member 1 (ACSBG1) is an enzyme that in humans is encoded by the ACSBG1 gene.^{[1] [2] [3]}

The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis.^[3] The conversion of long chain fatty acids into long chain acyl-CoAs in mice is catalysed by ACSBG1.^[4]

Further reading

• Andersson B, Wentland MA, Ricafrente JY . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . etal.
• Yu W, Andersson B, Worley KC . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . etal.
• Moriya-Sato A, Hida A, Inagawa-Ogashiwa M . Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues. . Biochem. Biophys. Res. Commun. . 279 . 1 . 62–8 . 2001 . 11112418 . 10.1006/bbrc.2000.3897 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Pei Z, Oey NA, Zuidervaart MM . The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.. . J. Biol. Chem. . 278 . 47 . 47070–8 . 2004 . 12975357 . 10.1074/jbc.M310075200 . etal. free .
• Fraisl P, Forss-Petter S, Zigman M, Berger J . Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase. . Biochem. J. . 377 . Pt 1 . 85–93 . 2004 . 14516277 . 10.1042/BJ20031062 . 1223850 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Asheuer M, Bieche I, Laurendeau I . Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy. . Hum. Mol. Genet. . 14 . 10 . 1293–303 . 2005 . 15800013 . 10.1093/hmg/ddi140 . etal. free .

Notes and References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 3 . 169–76 . Dec 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
2. Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA . Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids . J Biol Chem . 275 . 45 . 35162–9 . Nov 2000 . 10954726 . 10.1074/jbc.M006403200 . free .
3. Web site: Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1.
4. Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues. . Moriya-Sato A . Biochem Biophys Res Commun . Dec 2000 . 279 . 1 . 62–8 . 10.1006/bbrc.2000.3897 . 11112418. etal.