ACPD explained

1-Amino-1,3-dicarboxycyclopentane (ACPD) is a chemical compound that binds to the metabotropic glutamate receptor (mGluR),^[1] acting as a mGluR agonist. ACPD is a rigid analogue of the neurotransmitter glutamate and does not activate ionotropic glutamate receptors.^[2] However, it has been reported to be an agonist of the glycine site of the NMDA receptor. ACPD can induce convulsions in neonatal rats.^[3]

Notes and References

1. Schoepp DD, True RA . 1S,3R-ACPD-sensitive (metabotropic) [³H]glutamate receptor binding in membranes |journal=Neurosci. Lett. |volume=145 |issue=1 |pages=100–4 |date=September 1992 |pmid=1461560 |doi= 10.1016/0304-3940(92)90213-Q|s2cid=34921347 .
2. Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J . (trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes . Mol. Pharmacol. . 38 . 1 . 1–6 . July 1990 . 2164627 .
3. McDonald JW, Fix AS, Tizzano JP, Schoepp DD . Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist . J. Neurosci. . 13 . 10 . 4445–55 . October 1993 . 8410197 . 6576384 . 10.1523/JNEUROSCI.13-10-04445.1993.