ACP2 explained

Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.^{[1] [2]}

Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.^[2]

Further reading

• Moss DW, Raymond FD, Wile DB . Clinical and biological aspects of acid phosphatase. . Critical Reviews in Clinical Laboratory Sciences . 32 . 4 . 431–67 . 1995 . 7576159 . 10.3109/10408369509084690 .
• Gierek T, Lisiewicz T, Pilch J . Intracellular enzymatic response of lymphocytes and neutrophils in patients with cancer of the larynx. . Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. . 104 . 2 . 208–15 . 1977 . 69583 .
• Jones C, Kao FT . Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11. . Hum. Genet. . 45 . 1 . 1–10 . 1979 . 730175 . 10.1007/BF00277567 . 21173503 .
• Geier C, von Figura K, Pohlmann R . Structure of the human lysosomal acid phosphatase gene. . Eur. J. Biochem. . 183 . 3 . 611–6 . 1989 . 2776754 . 10.1111/j.1432-1033.1989.tb21090.x .
• Lemansky P, Gieselmann V, Hasilik A, von Figura K . Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts. . J. Biol. Chem. . 260 . 15 . 9023–30 . 1985 . 10.1016/S0021-9258(17)39452-8 . 3160696 . free .
• Pohlmann R, Krentler C, Schmidt B . Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment. . EMBO J. . 7 . 8 . 2343–50 . 1989 . 3191910 . 10.1002/j.1460-2075.1988.tb03078.x. 457099 . etal.
• Waheed A, Van Etten RL . Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells. . Arch. Biochem. Biophys. . 243 . 1 . 274–83 . 1985 . 3904632 . 10.1016/0003-9861(85)90796-9 .
• Nadler HL, Egan TJ . Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder. . N. Engl. J. Med. . 282 . 6 . 302–7 . 1970 . 5410815 . 10.1056/NEJM197002052820604 .
• Bass DA, Lewis JC, Szejda P . Activation of lysosomal acid phosphatase of eosinophil leukocytes. . Lab. Invest. . 44 . 5 . 403–9 . 1981 . 6164873 . etal.
• Chappard D, Alexandre C, Riffat G . Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies. . Basic and Applied Histochemistry . 27 . 2 . 75–85 . 1983 . 6193776 .
• Moszczyński P, Lisiewicz J . Beta-glucuronidase of lymphocytes in ontogenetic development of man. . Arch. Immunol. Ther. Exp. (Warsz.) . 31 . 2 . 171–6 . 1984 . 6651479 .
• Radzun HJ, Parwaresch MR . Isoelectric focusing pattern of acid phosphatase and acid esterase in human blood cells, including thymocytes, T lymphocytes, and B lymphocytes. . Exp. Hematol. . 8 . 6 . 737–41 . 1981 . 6970673 .
• Andersson B, Wentland MA, Ricafrente JY . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . etal.
• Whitelock RB, Fukuchi T, Zhou L . Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas. . Invest. Ophthalmol. Vis. Sci. . 38 . 2 . 529–34 . 1997 . 9040486 . etal.
• Yu W, Andersson B, Worley KC . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . etal.
• Obermüller S, Kiecke C, von Figura K, Höning S . The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targeting to lysosomes. . J. Cell Sci. . 115 . Pt 1 . 185–94 . 2002 . 10.1242/jcs.115.1.185 . 11801736 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Shows TB, Brown JA, Lalley PA . Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11 . Cytogenet Cell Genet . 16 . 1–5 . 231–4 . Dec 1976 . 975882 . 10.1159/000130598 .
2. Web site: Entrez Gene: ACP2 acid phosphatase 2, lysosomal.