ACP-SH:acetate ligase explained

Acetate—[acyl-carrier protein] ligase
Ec Number:	6.2.1.35

Acetate—[acyl-carrier protein] ligase (HS-acyl-carrier protein:acetate ligase, [acyl-carrier protein]:acetate ligase, MadH) is an enzyme with systematic name acetate:(acyl-carrier-protein) ligase (AMP-forming).^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

ATP + acetate + an [acyl-carrier protein]

\rightleftharpoons AMP + diphosphate + an acetyl-[acyl-carrier protein]

This enzyme, from the anaerobic bacterium Malonomonas rubra, is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase.

Notes and References

1. Hilbi H, Dehning I, Schink B, Dimroth P . Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme . European Journal of Biochemistry . 207 . 1 . 117–23 . July 1992 . 1628643 . 10.1111/j.1432-1033.1992.tb17028.x . free .
2. Berg M, Hilbi H, Dimroth P . The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2'-(5"-phosphoribosyl)-3'-dephosphocoenzyme A as a prosthetic group . Biochemistry . 35 . 15 . 4689–96 . April 1996 . 8664258 . 10.1021/bi952873p .
3. Berg M, Hilbi H, Dimroth P . Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function . European Journal of Biochemistry . 245 . 1 . 103–15 . April 1997 . 9128730 . 10.1111/j.1432-1033.1997.00103.x . free .
4. Dimroth P, Hilbi H . Enzymic and genetic basis for bacterial growth on malonate . Molecular Microbiology . 25 . 1 . 3–10 . July 1997 . 11902724 . 10.1046/j.1365-2958.1997.4611824.x . free .