ACP-105 explained

ACP-105 is a drug which acts as a selective androgen receptor modulator (SARM). It has been investigated for potential use in the treatment of age-related cognitive decline.^{[1] [2] [3] [4]} The drug has been found to reduce anxiety-like behavior in a mouse model of Alzheimer's disease when administered alone, as well as enhance spatial memory when coadministered with the selective estrogen receptor β agonist AC-186. ACP-105 is an aniline SARM and is related to AC-262536 and vosilasarm (RAD140).^[5]

Notes and References

1. Schlienger N, Lund BW, Pawlas J, Badalassi F, Bertozzi F, Lewinsky R, Fejzic A, Thygesen MB, Tabatabaei A, Bradley SR, Gardell LR, Piu F, Olsson R . 6 . Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators . Journal of Medicinal Chemistry . 52 . 22 . 7186–7191 . November 2009 . 19856921 . 10.1021/jm901149c .
2. Dayger C, Villasana L, Pfankuch T, Davis M, Raber J . Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice . Brain Research . 1381 . 134–140 . March 2011 . 21219889 . 10.1016/j.brainres.2010.12.088 . 3048897 .
3. George S, Petit GH, Gouras GK, Brundin P, Olsson R . Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease . ACS Chemical Neuroscience . 4 . 12 . 1537–1548 . December 2013 . 24020966 . 10.1021/cn400133s . 3867967 .
4. Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P . Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes . Drug Testing and Analysis . October 2021 . 14 . 2 . 349–370 . 34714606 . 10.1002/dta.3189 . 240152623 . 1854/LU-8740373 . free .
5. Zhang X, Sui Z . Deciphering the selective androgen receptor modulators paradigm . Expert Opinion on Drug Discovery . 8 . 2 . 191–218 . February 2013 . 23231475 . 10.1517/17460441.2013.741582 . 2584722 .