Aminocarboxymuconate-semialdehyde decarboxylase explained

aminocarboxymuconate-semialdehyde decarboxylase
Altnames:	ACMSD
Ec Number:	4.1.1.45
Cas Number:	37289-47-7
Go Code:	0001760
Width:	270

The enzyme aminocarboxymuconate-semialdehyde decarboxylase catalyzes the chemical reaction

2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate

\rightleftharpoons 2-aminomuconate semialdehyde + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. This enzyme participates in tryptophan metabolism. It has been identified as a marker in nonverbal autism.^[1]

Nomenclature

The systematic name of this enzyme class is 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming). Other names in common use include picolinic acid carboxylase, picolinic acid decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde, beta-decarboxylase, 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase, and 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase.

Further reading

• Ichiyama A, Nakamura S, Kawai H, Honjo T, Nishizuka Y, Hayaishi O, Senoh S . Studies on the Metabolism of the Benzene Ring of Tryptophan in Mammalian Tissues. II. Enzymic Formation of Alpha-Aminomuconic Acid from 3-Hydroxyanthranilic Acid . The Journal of Biological Chemistry . 240 . 740–9 . February 1965 . 2 . 10.1016/S0021-9258(17)45238-0 . 14275130 . free.

Notes and References

1. Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorder . 2023 . Kainer . David . Templeton . Alan R. . Prates . Erica T. . Jacboson . Daniel . Allan . Euan R.O. . Climer . Sharlee . Garvin . Michael R. . Human Genetics and Genomics Advances . 4 . 1 . 100150 . 10.1016/j.xhgg.2022.100150 . 36340933 . 9634371.