ACIN1 explained

Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene.^{[1] [2] [3]}

Further reading

• Zermati Y, Garrido C, Amsellem S . Caspase activation is required for terminal erythroid differentiation. . J. Exp. Med. . 193 . 2 . 247–54 . 2001 . 11208865 . 10.1084/jem.193.2.247 . 2193347 . etal.
• Sordet O, Rébé C, Plenchette S . Specific involvement of caspases in the differentiation of monocytes into macrophages. . Blood . 100 . 13 . 4446–53 . 2003 . 12393560 . 10.1182/blood-2002-06-1778 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Shu H, Chen S, Bi Q . Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. . Mol. Cell. Proteomics . 3 . 3 . 279–86 . 2004 . 14729942 . 10.1074/mcp.D300003-MCP200 . etal. free .
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . etal. 2004PNAS..10112130B . free .
• Jin J, Smith FD, Stark C . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . etal. free . 2004CBio...14.1436J .
• Kim JE, Tannenbaum SR, White FM . Global phosphoproteome of HT-29 human colon adenocarcinoma cells. . J. Proteome Res. . 4 . 4 . 1339–46 . 2005 . 16083285 . 10.1021/pr050048h .
• Hu Y, Yao J, Liu Z . Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. . EMBO J. . 24 . 20 . 3543–54 . 2005 . 16177823 . 10.1038/sj.emboj.7600823 . 1276706 . etal.
• Joselin AP, Schulze-Osthoff K, Schwerk C . Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. . J. Biol. Chem. . 281 . 18 . 12475–84 . 2006 . 16537548 . 10.1074/jbc.M509859200 . free .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . etal. free .
• Shu Y, Iijima T, Sun W . The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma. . Journal of Thoracic Oncology . 1 . 2 . 160–7 . 2007 . 17409846 . 10.1097/01243894-200602000-00010. etal.

Notes and References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 3 . 169–76 . Dec 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
2. Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y . Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation . Nature . 401 . 6749 . 168–73 . Sep 1999 . 10490026 . 10.1038/43678 . 1999Natur.401..168S . 4364282 .
3. Web site: Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1.