ACER2 explained

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.^[1]

Function

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.^[2]

Further reading

• Xu R, Jin J, Hu W . Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. . FASEB J. . 20 . 11 . 1813–25 . 2006 . 16940153 . 10.1096/fj.05-5689com. free . 20973940 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Humphray SJ, Oliver K, Hunt AR . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Wan D, Gong Y, Qin W . Large-scale cDNA transfection screening for genes related to cancer development and progression. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842. 2004PNAS..10115724W . etal. free .

Notes and References

1. Mao C, Obeid LM . Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate . Biochim. Biophys. Acta . 1781 . 9 . 424–34 . September 2008 . 18619555 . 10.1016/j.bbalip.2008.06.002 . 2614331 .
2. Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C . Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion . FASEB J. . 23 . 2 . 656–66 . February 2009 . 18945876 . 10.1096/fj.08-115634 . free . 2630785 .