ACBD3 explained

Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.

Function

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. ACBD3 is involved in maintaining the Golgi structure by interacting with giantin, which affects the transport of protein.^[1] The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation.^[2]

Interactions

ACBD3 has been shown to interact with GOLGB1.^[3]

Further reading

• Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y . Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin. . J. Biol. Chem. . 276 . 48 . 45298–306 . 2002 . 11590181 . 10.1074/jbc.M108961200 . free .
• Li H, Degenhardt B, Tobin D, Yao ZX, Tasken K, Papadopoulos V . Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein. . Mol. Endocrinol. . 15 . 12 . 2211–28 . 2002 . 10.1210/mend.15.12.0736 . 11731621 . 27565320 . free .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Liu J, Matyakhina L, Han Z, Sandrini F, Bei T, Stratakis CA, Papadopoulos V . Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues . FASEB J. . 17 . 9 . 1189–91 . 2003 . 12692076 . 10.1096/fj.02-1066fje . free . 19079882 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Sbodio JI, Hicks SW, Simon D, Machamer CE . GCP60 preferentially interacts with a caspase-generated golgin-160 fragment . J. Biol. Chem. . 281 . 38 . 27924–31 . 2006 . 16870622 . 10.1074/jbc.M603276200 . free .
• Sbodio JI, Machamer CE . Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160 . J. Biol. Chem. . 282 . 41 . 29874–81 . 2007 . 17711851 . 10.1074/jbc.M705794200 . free.

Notes and References

1. Web site: ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein.
2. Web site: Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3.
3. Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y . Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin . J. Biol. Chem. . 276 . 48 . 45298–306 . November 2001 . 11590181 . 10.1074/jbc.M108961200 . free .