ACAD10 explained

Acyl-CoA dehydrogenase family, member 10 is a protein that in humans is encoded by the ACAD10 gene.^[1]

Structure

This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catalytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Clinical significance

In Pima people, ACAD10 has been identified as a gene associated with type 2 diabetes, insulin resistance, and impaired lipid metabolism. Specifically, two single nucleotide polymorphisms, rs601663 and rs659964, have been significantly correlated with these symptoms in a large population of both the Pima people and American Indians.^[2]

Interactions

Using affinity capture mass spectrometry, an interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. Using this method, ACAD10 has been shown to interact with P2RY8, NDUFA10, NTRK3, SLC2A12, LPAR4, PTH1R, COLEC10, APP, MAS1, CD79A, BSG, and Ubiquitin C.^[3]

Further reading

• Ye X, Ji C, Zhou C, Zeng L, Gu S, Ying K, Xie Y, Mao Y . Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1 . Molecular Biology Reports . 31 . 3 . 191–5 . Sep 2004 . 15560374 . 10.1023/b:mole.0000043622.57408.6b. 6678439 .
• Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A . Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study . Gynecologic Oncology . 112 . 1 . 210–4 . Jan 2009 . 18950845 . 10.1016/j.ygyno.2008.09.012 .
• He M, Pei Z, Mohsen AW, Watkins P, Murdoch G, Van Veldhoven PP, Ensenauer R, Vockley J . Identification and characterization of new long chain acyl-CoA dehydrogenases . Molecular Genetics and Metabolism . 102 . 4 . 418–29 . Apr 2011 . 21237683 . 3073726 . 10.1016/j.ymgme.2010.12.005 .
• Qayyum R, Snively BM, Ziv E, Nalls MA, Liu Y, Tang W, Yanek LR, Lange L, Evans MK, Ganesh S, Austin MA, Lettre G, Becker DM, Zonderman AB, Singleton AB, Harris TB, Mohler ER, Logsdon BA, Kooperberg C, Folsom AR, Wilson JG, Becker LC, Reiner AP . A meta-analysis and genome-wide association study of platelet count and mean platelet volume in African Americans . PLOS Genetics . 8 . 3 . e1002491 . 2012 . 22423221 . 3299192 . 10.1371/journal.pgen.1002491 . free .
• Lee JY, Lee BS, Shin DJ, Woo Park K, Shin YA, Joong Kim K, Heo L, Young Lee J, Kyoung Kim Y, Jin Kim Y, Bum Hong C, Lee SH, Yoon D, Jung Ku H, Oh IY, Kim BJ, Lee J, Park SJ, Kim J, Kawk HK, Lee JE, Park HK, Lee JE, Nam HY, Park HY, Shin C, Yokota M, Asano H, Nakatochi M, Matsubara T, Kitajima H, Yamamoto K, Kim HL, Han BG, Cho MC, Jang Y, Kim HS, Euy Park J, Lee JY . A genome-wide association study of a coronary artery disease risk variant . Journal of Human Genetics . 58 . 3 . 120–6 . Mar 2013 . 23364394 . 10.1038/jhg.2012.124 . free .
• Bian L, Hanson RL, Muller YL, Ma L, Kobes S, Knowler WC, Bogardus C, Baier LJ . Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians . Diabetologia . 53 . 7 . 1349–53 . Jul 2010 . 20390405 . 2947857 . 10.1007/s00125-010-1695-y .
• Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y, Liu Z, Zhan Q, Liu Y, Yu D, Zhai K, Chang J, Qiao Y, Jin G, Liu Z, Shen Y, Guo C, Fu J, Miao X, Tan W, Shen H, Ke Y, Zeng Y, Wu T, Lin D . Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations . Nature Genetics . 43 . 7 . 679–84 . Jul 2011 . 21642993 . 10.1038/ng.849 . 205357759 .

Notes and References

1. Web site: Entrez Gene: Acyl-CoA dehydrogenase family, member 10 .
2. Bian L, Hanson RL, Muller YL, Ma L, Kobes S, Knowler WC, Bogardus C, Baier LJ . Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians . Diabetologia . 53 . 7 . 1349–53 . Jul 2010 . 20390405 . 10.1007/s00125-010-1695-y . 2947857.
3. Web site: ACAD10 Results Summary. BioGrid. TheTyerslab.com. 18 May 2015.