AC-42 explained

AC-42 is a selective, allosteric agonist of the M1 muscarinic acetylcholine receptor. AC-42 was the first selective M1 agonist to be discovered and its derivatives have been used to study the binding domain of the M1 receptor.[1] [2] [3]

Notes and References

  1. Decker . Michael . Holzgrabe . Ulrike . M1 muscarinic cetylcholine receptor allosteric modulators as potential therapeutic opportunities for treating Alzheimer's disease . MedChemComm . 2012 . 3 . 7 . 752 . 10.1039/c2md20025b.
  2. Sams . Anette G. . Hentzer . Morten . Mikkelsen . Gitte K. . Larsen . Krestian . Bundgaard . Christoffer . Plath . Niels . Christoffersen . Claus T. . Bang-Andersen . Benny . Discovery of N --2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential . Journal of Medicinal Chemistry . 9 September 2010 . 53 . 17 . 6386–6397 . 10.1021/jm100697g. 20684563 .
  3. Daval . Sandrine B. . Valant . Céline . Bonnet . Dominique . Kellenberger . Esther . Hibert . Marcel . Galzi . Jean-Luc . Ilien . Brigitte . Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors . Journal of Medicinal Chemistry . 8 March 2012 . 55 . 5 . 2125–2143 . 10.1021/jm201348t. 22329602 .

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