ABTB1 explained

Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.^{[1] [2]}

Function

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants encoding different isoforms.^[3]

Further reading

• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Wan D, Gong Y, Qin W . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842 . 2004PNAS..10115724W . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Colland F, Jacq X, Trouplin V . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .

Notes and References

1. Dai KS, Wei W, Liew CC . Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain . Biochem Biophys Res Commun . 273 . 3 . 991–6 . Sep 2000 . 10891360 . 10.1006/bbrc.2000.3053 .
2. Unoki M, Nakamura Y . Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway . Oncogene . 20 . 33 . 4457–65 . Aug 2001 . 11494141 . 10.1038/sj.onc.1204608 . free .
3. Web site: Entrez Gene: ABTB1 ankyrin repeat and BTB (POZ) domain containing 1.