ABT-670 explained

ABT-670 is a drug which acts as a potent, orally bioavailable dopamine agonist selective for the D₄ subtype, which was developed as a possible treatment for erectile dysfunction,^[1] although its current uses are limited to scientific research.^[2]

See also

• ABT-724
• Bremelanotide
• Cabergoline
• Flibanserin
• Intrinsa
• Melanotan II
• Pramipexole
• PF-219,061
• Tibolone
• UK-414,495

Notes and References

1. Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M, Miller LN, Uchic ME, Terranova MA, El-Kouhen OF, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Chang R, Martino BR, Wetter JM, Marsh KC, Martin R, Darbyshire JF, Gintant G, Hsieh GC, Moreland RB, Sullivan JP, Brioni JD, Stewart AO . 6 . Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction . Journal of Medicinal Chemistry . 49 . 25 . 7450–65 . December 2006 . 17149874 . 10.1021/jm060662k .
2. Richards N, Wayman C, Allers KA . Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection . Neuroscience Letters . 465 . 3 . 242–7 . November 2009 . 19733217 . 10.1016/j.neulet.2009.08.078 . 27767274 .