ABRA (gene) explained

Actin-binding Rho-activating protein is a protein that in humans is encoded by the ABRA gene.^[1] The mouse and rat homologues are known as STARS (striated muscle activator of Rho signalling) and MS1 (myocyte stress 1) respectively.^[2]

MS1/STARS is regulated by MyoD during myogenic differentiation of the C2C12 cell line.

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Simpson JC, Wellenreuther R, Poustka A . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wiemann S, Arlt D, Huber W . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Kuwahara K, Barrientos T, Pipes GC . Muscle-specific signaling mechanism that links actin dynamics to serum response factor. . Mol. Cell. Biol. . 25 . 8 . 3173–81 . 2005 . 15798203 . 10.1128/MCB.25.8.3173-3181.2005 . 1069631 . etal.
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.
• Kuwahara K, Teg Pipes GC, McAnally J . Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity. . J. Clin. Invest. . 117 . 5 . 1324–34 . 2007 . 17415416 . 10.1172/JCI31240 . 1838928 . etal.

Notes and References

1. Arai A, Spencer JA, Olson EN . STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription . J Biol Chem . 277 . 27 . 24453–9 . Jul 2002 . 11983702 . 10.1074/jbc.M202216200 . free.
2. Web site: Entrez Gene: ABRA actin-binding Rho activating protein.