ABI gene family member 3 explained

ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.^{[1] [2] [3]}

Function

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.^[3]

See also

• ABI1
• ABI2
• ABI3BP

Further reading

• Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S . In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review). . Int. J. Mol. Med. . 9 . 6 . 591–5 . 2002 . 12011975 . 10.3892/ijmm.9.6.591.
• Miyazaki K, Matsuda S, Ichigotani Y . Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein . Biochim. Biophys. Acta . 1493 . 1–2 . 237–41 . 2000 . 10978530 . 10.1016/s0167-4781(00)00158-5. etal.
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Matsuda S, Iriyama C, Yokozaki S . Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. . J. Hum. Genet. . 46 . 8 . 483–6 . 2001 . 11501947 . 10.1007/s100380170049 . etal. free .
• Ichigotani Y, Yokozaki S, Fukuda Y . Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. . Cancer Res. . 62 . 8 . 2215–9 . 2002 . 11956071 . etal.
• Wiemann S, Arlt D, Huber W . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.
• Hirao N, Sato S, Gotoh T . NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. . FEBS Lett. . 580 . 27 . 6464–70 . 2007 . 17101133 . 10.1016/j.febslet.2006.10.065 . 20005197 . etal. free .

Notes and References

1. Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M . Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein . Biochim Biophys Acta . 1493 . 1–2 . 237–41 . Nov 2000 . 10978530 . 10.1016/s0167-4781(00)00158-5.
2. Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S . Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells . Cancer Res . 62 . 8 . 2215–9 . Apr 2002 . 11956071 .
3. Web site: Entrez Gene: ABI3 ABI gene family, member 3.