ABI2 explained

Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.^{[1] [2] [3]}

Interactions

ABI2 has been shown to interact with ABL1,^{[1] [4]} ADAM19,^[5] and TRIM32.^[6]

Further reading

• Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S . In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review). . Int. J. Mol. Med. . 9 . 6 . 591–5 . 2002 . 12011975 . 10.3892/ijmm.9.6.591.
• Wang B, Mysliwiec T, Krainc D . Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. . Oncogene . 12 . 9 . 1921–9 . 1996 . 8649853 . etal.
• Juang JL, Hoffmann FM . Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. . Oncogene . 18 . 37 . 5138–47 . 1999 . 10498863 . 10.1038/sj.onc.1202911 . free .
• Chen B, Borinstein SC, Gillis J . The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes. . J. Biol. Chem. . 275 . 25 . 19275–81 . 2000 . 10858458 . 10.1074/jbc.M908994199 . etal. free .
• Machado RD, Pauciulo MW, Fretwell N . A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium. . Genomics . 68 . 2 . 220–8 . 2001 . 10964520 . 10.1006/geno.2000.6291 . etal.
• Courtney KD, Grove M, Vandongen H . 7370589 . Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system. . Mol. Cell. Neurosci. . 16 . 3 . 244–57 . 2000 . 10995551 . 10.1006/mcne.2000.0865 . etal.
• Stradal T, Courtney KD, Rottner K . The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. . Curr. Biol. . 11 . 11 . 891–5 . 2001 . 11516653 . 10.1016/S0960-9822(01)00239-1 . 1861695 . etal. free . 2001CBio...11..891S .
• Huang L, Feng L, Yang L . Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. . Mol. Biol. Rep. . 29 . 3 . 317–23 . 2003 . 12463424 . 10.1023/A:1020409217215 . 22611084 . etal.
• Mammalian Gene Collection Program Team . 4 . Strausberg . R. L. . Feingold . E. A. . Grouse . L. H. . Derge . J. G. . Klausner . R. D. . Collins . F. S. . Wagner . L. . Shenmen . C. M. . Schuler . G. D. . 10.1073/pnas.242603899 . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . . 99 . 26 . 16899–16903 . 139241 . 2002 . 12477932. 2002PNAS...9916899M . free .
• Cao C, Leng Y, Li C, Kufe D . Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response . J. Biol. Chem. . 278 . 15 . 12961–7 . 2003 . 12569093 . 10.1074/jbc.M300058200 . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Eastman SW, Martin-Serrano J, Chung W . Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding . J. Biol. Chem. . 280 . 1 . 628–36 . 2005 . 15509564 . 10.1074/jbc.M410384200 . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Luo X, Levens E, Williams RS, Chegini N . The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta . Hum. Reprod. . 21 . 6 . 1380–6 . 2006 . 16488906 . 10.1093/humrep/del011 . free .
• Hirao N, Sato S, Gotoh T . NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation . FEBS Lett. . 580 . 27 . 6464–70 . 2007 . 17101133 . 10.1016/j.febslet.2006.10.065 . 20005197 . etal. free .
• Li Y, Clough N, Sun X . BCR-ABL Induces Abnormal Cytoskeleton Remodeling, β1 Integrin Clustering, and Increased Cell Adhesion to Fibronectin Through ABL Interactor 1 Pathway . J. Cell Sci. . 120 . Pt 8 . 1436–46 . 2007 . 17389688 . 10.1242/jcs.03430 . 1950936 . etal.

Notes and References

1. Dai Z, Pendergast AM . Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity . Genes Dev . 9 . 21 . 2569–82 . Dec 1995 . 7590236 . 10.1101/gad.9.21.2569 . free .
2. Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC . A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium . Genomics . 68 . 2 . 220–8 . Sep 2000 . 10964520 . 10.1006/geno.2000.6291 .
3. Web site: Entrez Gene: ABI2 abl interactor 2.
4. Cao C, Leng Y, Li C, Kufe D . Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response . J. Biol. Chem. . 278 . 15 . 12961–7 . April 2003 . 12569093 . 10.1074/jbc.M300058200 . free .
5. Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C . Screen and identification of proteins interacting with ADAM19 cytoplasmic tail . Mol. Biol. Rep. . 29 . 3 . 317–23 . September 2002 . 12463424 . 10.1023/A:1020409217215. 22611084 .
6. Kano S, Miyajima N, Fukuda S, Hatakeyama S . Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2 . Cancer Res. . 68 . 14 . 5572–80 . July 2008 . 18632609 . 10.1158/0008-5472.CAN-07-6231 . free .