ABCF1 explained

ATP-binding cassette sub-family F member 1 is a protein that in humans is encoded by the ABCF1 gene.^[1]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains, characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancing protein synthesis and inflammation.^[2]

See also

• ATP-binding cassette transporter

Further reading

• Klein I, Sarkadi B, Váradi A . An inventory of the human ABC proteins. . Biochim. Biophys. Acta . 1461 . 2 . 237–62 . 2000 . 10581359 . 10.1016/s0005-2736(99)00161-3. free .
• You KT, Li LS, Kim NG . Selective Translational Repression of Truncated Proteins from Frameshift Mutation-Derived mRNAs in Tumors . PLOS Biol. . 5 . 5 . e109 . 2007 . 17456004 . 10.1371/journal.pbio.0050109 . 1854916 . etal . free .
• Ota M, Katsuyama Y, Hamano H . Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis . Immunogenetics . 59 . 1 . 45–52 . 2007 . 17119950 . 10.1007/s00251-006-0178-2 . 23164855 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ballif BA, Villén J, Beausoleil SA . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . etal. free .
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . etal. free .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Tyzack JK, Wang X, Belsham GJ, Proud CG . ABC50 interacts with eukaryotic initiation factor 2 and associates with the ribosome in an ATP-dependent manner . J. Biol. Chem. . 275 . 44 . 34131–9 . 2000 . 10931828 . 10.1074/jbc.M002868200 . free .

Notes and References

1. Richard M, Drouin R, Beaulieu AD . ABC50, a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes . Genomics . 53 . 2 . 137–45 . Dec 1998 . 9790762 . 10.1006/geno.1998.5480 .
2. Web site: Entrez Gene: ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1.