ABCC10 explained

Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.^{[1] [2]}

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.^[2]

See also

• ATP-binding cassette transporter

Further reading

• Hopper E, Belinsky MG, Zeng H . Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. . Cancer Lett. . 162 . 2 . 181–91 . 2001 . 11146224 . 10.1016/S0304-3835(00)00646-7 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Chen ZS, Hopper-Borge E, Belinsky MG . Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). . Mol. Pharmacol. . 63 . 2 . 351–8 . 2003 . 12527806 . 10.1124/mol.63.2.351 . 26642179 . etal.
• Kao HH, Chang MS, Cheng JF, Huang JD . Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. . J. Biomed. Sci. . 10 . 1 . 98–110 . 2003 . 12566991 . 10.1159/000068078 . 202649323 .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . etal. 2003Natur.425..805M . 4423608 . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . 21903526 . etal. free .
• Hopper-Borge E, Chen ZS, Shchaveleva I . Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. . Cancer Res. . 64 . 14 . 4927–30 . 2004 . 15256465 . 10.1158/0008-5472.CAN-03-3111 . 6933602 . etal. free .
• Wooden SL, Kalb SR, Cotter RJ, Soloski MJ . Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis. . J. Immunol. . 175 . 3 . 1383–7 . 2005 . 16034073 . 10.4049/jimmunol.175.3.1383. 22554947 . free .
• Naramoto H, Uematsu T, Uchihashi T . Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines. . Int. J. Oncol. . 30 . 2 . 393–401 . 2007 . 17203221 . 10.3892/ijo.30.2.393 . etal. 31 January 2024 .

Notes and References

1. Allikmets R, Gerrard B, Hutchinson A, Dean M . Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. . Hum Mol Genet . 5 . 10 . 1649–55 . Feb 1997 . 8894702 . 10.1093/hmg/5.10.1649 . free .
2. Web site: Entrez Gene: ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10.