ABCA8 explained

ABC-type organic anion transporter ABCA8 is a protein that in humans is encoded by the ABCA8 gene.^[1]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a member of the ABCA subfamily. Members of the ABCA subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes.^[1]

Further reading

• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Mammalian Gene Collection Program Team . 4 . Strausberg . R. L. . Feingold . E. A. . Grouse . L. H. . Derge . J. G. . Klausner . R. D. . Collins . F. S. . Wagner . L. . Shenmen . C. M. . Schuler . G. D. . 10.1073/pnas.242603899 . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . . 99 . 26 . 16899–16903 . 139241 . 2002 . 12477932. 2002PNAS...9916899M . free .
• Tsuruoka S, Ishibashi K, Yamamoto H . Functional analysis of ABCA8, a new drug transporter. . Biochem. Biophys. Res. Commun. . 298 . 1 . 41–5 . 2002 . 12379217 . 10.1016/S0006-291X(02)02389-6 . etal.
• Iida A, Saito S, Sekine A . Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. . J. Hum. Genet. . 47 . 6 . 285–310 . 2002 . 12111378 . 10.1007/s100380200041 . etal. free .
• Harrington JJ, Sherf B, Rundlett S . Creation of genome-wide protein expression libraries using random activation of gene expression. . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . 25064683 . etal.
• Nagase T, Ishikawa K, Suyama M . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 5 . 6 . 355–64 . 1999 . 10048485 . 10.1093/dnares/5.6.355 . etal. free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Web site: ABCA8 ATP binding cassette subfamily A member 8 [Homo sapiens (human) ]].