AB-PINACA explained

AB-PINACA is a compound that was first identified as a component of synthetic cannabis products in Japan in 2012.[1]

It was originally developed by Pfizer in 2009 as an analgesic medication.[2] [3]

AB-PINACA acts as a potent agonist for the CB1 receptor (Ki = 2.87 nM, EC50 = 1.2 nM) and CB2 receptor (Ki = 0.88 nM, EC50 = 2.5 nM) and fully substitutes for Δ9-THC in rat discrimination studies, while being 1.5x more potent.[4] [5]

There have been a number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid.[6] [7]

Legal status

Germany

AB-PINACA is an Anlage II controlled substance in Germany as of November 2014.[8]

Singapore

It is listed in the Fifth Schedule of the Misuse of Drugs Act and so is illegal in Singapore, as of May 2015.[9]

United States

It is a Schedule I controlled substance in the United States.[10]

China

It is a controlled substance in China as of October 2015.[11]

France

It is a controlled substance in France as of March 2017.[12]

See also

Notes and References

  1. Uchiyama N, Matsuda S, Wakana D, Kikura-Hanajiri R, Goda Y . New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products . 10.1007/s11419-012-0171-4 . Forensic Toxicology . 31 . 93–100 . 2012 . 25242453 .
  2. Web site: AB-PINACA. Cayman Chemical . 25 June 2015.
  3. Indazole derivatives . WO . 2009106980A . Buchler IP, Hayes MJ, Hegde SG, Hockerman SL, Jones DE, Kortum SW, Rico JG, Tenbrink RE, Wu KK . Pfizer Inc. . 3 September 2009 .
  4. Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Glass M, Connor M, McGregor IS, Kassiou M . 6 . Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA . ACS Chemical Neuroscience . 6 . 9 . 1546–1559 . September 2015 . 26134475 . 10.1021/acschemneuro.5b00112 .
  5. Wiley JL, Marusich JA, Lefever TW, Antonazzo KR, Wallgren MT, Cortes RA, Patel PR, Grabenauer M, Moore KN, Thomas BF . 6 . AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice . The Journal of Pharmacology and Experimental Therapeutics . 354 . 3 . 328–339 . September 2015 . 26105953 . 4538877 . 10.1124/jpet.115.225326 .
  6. Trecki J, Gerona RR, Schwartz MD . Synthetic Cannabinoid-Related Illnesses and Deaths . The New England Journal of Medicine . 373 . 2 . 103–107 . July 2015 . 26154784 . 10.1056/NEJMp1505328 .
  7. Thornton SL, Akpunonu P, Glauner K, Hoehn KS, Gerona R . Unintentional Pediatric Exposure to a Synthetic Cannabinoid (AB-PINACA) Resulting in Coma and Intubation . Annals of Emergency Medicine . 66 . 3 . 343–344 . September 2015 . 26304261 . 10.1016/j.annemergmed.2015.05.021 .
  8. Web site: Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel) . Law on the Traffic in Narcotic Substances (Narcotics Act - BtMG) Annex II (to Section 1 Paragraph 1) (marketable but not prescription narcotics) . 22 June 2015.
  9. Web site: Misuse of Drugs Act . Central Narcotics Bureau (CNB) . 30 April 2015 . 24 July 2015 . https://web.archive.org/web/20150715045305/http://www.cnb.gov.sg/Libraries/CNB_Newsroom_Files/CNB_NR_-_30_Apr_2015.sflb.ashx . 15 July 2015 . dead .
  10. Web site: Schedules of controlled substances: Temporary placement of three synthetic cannabinoids into schedule I. Final order . Drug Enforcement Administration, U.S. Department of Justice . 30 January 2015 . 9 July 2015.
  11. Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . Notice on Issuing the Measures for the Listing and Control of Non-Medicinal Narcotic Drugs and Psychotropic Substances . China Food and Drug Administration . 27 September 2015 . zh . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . 1 October 2015 . dead .
  12. Web site: Arrêté du 31 mars 2017 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants . Order of March 31, 2017 amending the order of February 22, 1990 establishing the list of substances classified as narcotics . Legifrance . 6 April 2017 . fr . 6 April 2017.

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