AADAC explained

Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.^{[1] [2]}

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.^[2]

Further reading

• Probst MR, Jenö P, Meyer UA . Purification and characterization of a human liver arylacetamide deacetylase. . Biochem. Biophys. Res. Commun. . 177 . 1 . 453–9 . 1991 . 2043131 . 10.1016/0006-291X(91)92005-5 .
• Yamazaki K, Kusano K, Tadano K, Tanaka I . Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3. . Genomics . 44 . 2 . 248–50 . 1997 . 9299245 . 10.1006/geno.1997.4879 .
• Ozols J . Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase. . Biochemistry . 37 . 28 . 10336–44 . 1998 . 9665742 . 10.1021/bi9807916 .
• Mziaut H, Korza G, Hand AR . Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. . J. Biol. Chem. . 274 . 20 . 14122–9 . 1999 . 10318829 . 10.1074/jbc.274.20.14122 . etal. free .
• Trickett JI, Patel DD, Knight BL . Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation. . J. Biol. Chem. . 276 . 43 . 39522–32 . 2001 . 11481320 . 10.1074/jbc.M101764200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Saito S, Iida A, Sekine A . Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. . J. Hum. Genet. . 48 . 5 . 249–70 . 2003 . 12721789 . 10.1007/s10038-003-0021-7 . etal. free .
• Frick C, Atanasov AG, Arnold P . Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase. . J. Biol. Chem. . 279 . 30 . 31131–8 . 2004 . 15152005 . 10.1074/jbc.M313666200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R . Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. . J Biol Chem . 269 . 34 . 21650–6 . Sep 1994 . 10.1016/S0021-9258(17)31855-0 . 8063807 . free .
2. Web site: Entrez Gene: AADAC arylacetamide deacetylase (esterase).