| Country: | FRA |
| Type: | A |
| Route: | 42 |
| Map: | France A4X A42.svg |
| Length Km: | 52.3 |
| Direction A: | North |
| Direction B: | South |
| Terminus A: | A40 |
| Terminus B: | Lyon |
The A42 autoroute is a short motorway in France. Being completed in 1987, the road connects the city of Lyon to its junction with the A40 roughly 50 km north-east of Lyon.
| Exit/Junction | Destination | |
| Lyon-Avenue Jean Mermoz Autoroute commences in Lyon City Centre | ||
| (Lyon: porte de Croix-Barret) Towns served Lyon Centre, Périphérique () | ||
| (Villeurbanne Croix-Luizet-St Jean) Towns served: Villeurbanne Croix-Luizet, St Jean | ||
| (Vauix-en-Velin) Towns served: Vauix-en-Velin | ||
| Exchange A42-N346 Junction with Lyon ring road to Orange south | ||
| Exchange A42-A46 Junction with part of the Lyon ring road to Paris | ||
| (Parc de Miribel-Jonage) Towns served: Neyron and Miribel | ||
| (Beynost) Towns served: Beynost | ||
| Exchange A42-A432 Junction with the to Marseille | ||
| (Balan-Dagneux) Towns served: Montluel and Balan | ||
| (Pérouges) Towns served: Pérouges, Meximieux and Saint-Jean-de-Niost | ||
| (Ambérieu) Towns served: Ambérieu-en-Bugey | ||
| (Pont-d'Ain) Towns served: Pont-d'Ain | ||
| Exchange A42-A40 Junction with to Mâcon (north), Geneva (Switzerland) (east) and end of autoroute. | ||