A20 cells explained

A20 cells, also called ATCC TIB-208, is a cell line originally derived from B-cell lymphoma in an old BALB/c mouse.[1] AT20 cells are BALB/c lymphoma cells derived from spontaneous reticulum cell neoplasm.[2] ATCC TIB-208 cells originated from B-cell lymphoma in the reticulum cell sarcoma of an elderly BALB/c mouse.[3] A20 cells are used in medical research such as drug screening or vaccine target selection.[4] [5] [6] A20 cells are also highly responsive to immunomodulatory antibodies, and are therefore used frequently in immunotherapy drug studies.

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Notes and References

  1. Kim . KJ . Kanellopoulos-Langevin . C . Merwin . RM . Sachs . DH . Asofsky . R . Establishment and characterization of BALB/c lymphoma lines with B cell properties. . Journal of Immunology . 1979 . 122 . 2 . 549–554 . 10.4049/jimmunol.122.2.549 . 310843 . free .
  2. Priem . Dario . van Loo . Geert . Bertrand . Mathieu J. M. . 2020-05-01 . A20 and Cell Death-driven Inflammation . Trends in Immunology . en . 41 . 5 . 421–435 . 10.1016/j.it.2020.03.001 . 32241683 . 214771288 . 1471-4906.
  3. Web site: A20: Modeling B cell lymphoma in mice . 2022-12-05 . drugdevelopment.labcorp.com.
  4. Meziane el . K . Bhattacharyya . T . Armstrong . AC . Qian . C . Hawkins . RE . Stern . PL . Dermime . S . Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma. . International Journal of Cancer . 2004-10-10 . 111 . 6 . 910–920 . 10.1002/ijc.20332 . 15300803 . free .
  5. Siegel . S . Wagner . A . Kabelitz . D . Marget . M . Coggin J . Jr . Barsoum . A . Rohrer . J . Schmitz . N . Zeis . M . 9814435 . Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies. . Blood . 2003-12-15 . 102 . 13 . 4416–23 . 10.1182/blood-2003-01-0198 . 12869512 . free .
  6. Siegel . S . Wagner . A . Schmitz . N . Zeis . M . Induction of antitumour immunity using survivin peptide-pulsed dendritic cells in a murine lymphoma model. . British Journal of Haematology . 2003 . 122 . 6 . 911–4 . 10.1046/j.1365-2141.2003.04535.x . 12956760 . free .

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