9-Nor-9β-hydroxyhexahydrocannabinol explained

9-Nor-9β-hydroxyhexahydrocannabinol (9-nor-9beta-HHC; sometimes incorrectly confused with 11-nor-9β-hydroxyhexahydrocannabinol^[1]) is a cannabinoid first discovered from early modifications to the structure of THC, in a search for the simplest compound that could still fulfill the binding requirements to produce cannabis-like activity.^{[2] [3]}

11-Hydroxyhexahydrocannabinol is the structurally related methylene homologue of 11-nor-9β-hydroxyhexahydrocannabinol that has been found as a minor active metabolite of tetrahydrocannabinol, and also a metabolite of the trace cannabinoid hexahydrocannabinol.^[4]

See also

• AM-2389
• 9-Hydroxyhexahydrocannabinol
  • Hexahydrocannabinol 11-Hydroxyhexahydrocannabinol
• HU-243
• Nabilone

Notes and References

1. Web site: 9-Hydroxy-9-norhexahydrocannabinol .
2. Book: Johnson MR, Althuis TH, Bindra JS, Harbert CA, Melvin LS, Milne GM . Potent Analgetics Derived From 9-Nor-9β-Hydroxyhexahydrocannabinol . NIDA Research Monograph . 34 . 1980 . 68−74 .
3. Book: Melvin LS, Johnson MR . Rapaka RS, Makriyannis A. Structure-activity Relationships of the Cannabinoids . Relationships of Tricyclic and Nonclassical Bicyclic Cannabinoids . NIDA Research Monograph . 79 . 1987 . 31–47 . https://books.google.com/books?id=ux0JfEz6ZmgC&pg=PA31 .
4. Järbe TU, Hiltunen AJ, Lander N, Mechoulam R . Cannabimimetic activity (delta 1-THC cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons . Pharmacology, Biochemistry, and Behavior . 25 . 2 . 393–9 . August 1986 . 3020594 . 10.1016/0091-3057(86)90015-8 . 28373651 .