9-Hydroxyhexahydrocannabinol Explained

9-Hydroxyhexahydrocannabinol (9-OH-HHC) is a semi-synthetic derivative of tetrahydrocannabinol. It is formed as an impurity in the synthesis of Delta-8-THC,^[1] and retains activity in animal studies though with only around 1/10 the potency of Δ⁹-THC, with the 9α- and 9β- enantiomers having around the same potency.^[2]

See also

• 8-Hydroxyhexahydrocannabinol
• 9-Nor-9β-hydroxyhexahydrocannabinol
• 11-Hydroxyhexahydrocannabinol
• 11-Hydroxy-THC
• 11-Hydroxy-Delta-8-THC
• Cannabicitran
• Cannabitriol
• Delta-10-THC
• Hexahydrocannabinol

Notes and References

1. Garrett ER, Gouyette AJ, Roseboom H . Stability of tetrahydrocannabinols II . Journal of Pharmaceutical Sciences . 67 . 1 . 27–32 . January 1978 . 22740 . 10.1002/jps.2600670108 .
2. Reggio PH, McGaughey GB, Odear DF, Seltzman HH, Compton DR, Martin BR . A rational search for the separation of psychoactivity and analgesia in cannabinoids . Pharmacology, Biochemistry, and Behavior . 40 . 3 . 479–86 . November 1991 . 1806940 . 10.1016/0091-3057(91)90350-b . 23939720 .