8-Hydroxyamoxapine Explained

Drug Name:	8-Hydroxyamoxapine
Elimination Half-Life:	30 hours
Cas Number:	61443-78-5
Pubchem:	43656
Chemspiderid:	39784
Unii:	0D4T741I48
Chebi:	143289
Dtxsid:	DTXSID40210388
Iupac Name:	8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepin-3-ol
C:	17
H:	16
Cl:	1
N:	3
O:	2
Smiles:	C1CN(CCN1)C2=NC3=C(C=CC(=C3)O)OC4=C2C=C(C=C4)Cl
Stdinchi:	1S/C17H16ClN3O2/c18-11-1-3-15-13(9-11)17(21-7-5-19-6-8-21)20-14-10-12(22)2-4-16(14)23-15/h1-4,9-10,19,22H,5-8H2
Stdinchikey:	QDWNOKXUZTYVGO-UHFFFAOYSA-N

8-Hydroxyamoxapine is an active metabolite of the antidepressant drug amoxapine (Asendin). It contributes to amoxapine's pharmacology.^{[1] [2]} It is a serotonin-norepinephrine reuptake inhibitor (SNRI) with similar norepinephrine, but more serotonin, reuptake inhibition as its parent compound. It plays a part in balancing amoxapine's ratio of serotonin to norepinephrine transporter blockage.^[3]

See also

• 7-Hydroxyamoxapine

Notes and References

1. Jue SG, Dawson GW, Brogden RN . Amoxapine: a review of its pharmacology and efficacy in depressed states . Drugs . 24 . 1 . 1–23 . July 1982 . 7049659 . 10.2165/00003495-198224010-00001 . 7279867 .
2. Calvo B, García MJ, Pedraz JL, Mariño EL, Domínguez-Gil A . Pharmacokinetics of amoxapine and its active metabolites . International Journal of Clinical Pharmacology, Therapy, and Toxicology . 23 . 4 . 180–185 . April 1985 . 3997304 .
3. Midha KK, Hubbard JW, McKay G, Rawson MJ, Hsia D . The role of metabolites in a bioequivalence study II: amoxapine, 7-hydroxyamoxapine, and 8-hydroxyamoxapine . International Journal of Clinical Pharmacology and Therapeutics . 37 . 9 . 428–38 . September 1999 . 10507241 .