8-Azaguanine Explained
8-Azaguanine is a purine analog with the chemical formula C4H4N6O. It has been widely studied for its biological activity.[1] It shows antineoplastic activity and has been used in the treatment of acute leukemia.
Use in chemotherapy
The compound closely resembles guanine and appears to be competitive with it in the metabolism of living organisms.[2] It has been shown to cause retardation of some malignant neoplasms when administered to tumors in animals. 8-Azaguanine was the first purine analogue discovered to inhibit experimental tumors in mice.[3]
Synonyms
- 2-Amino-6-hydroxy-8-azapurine
- 2-Amino-6-oxy-8-azapurine
- 5-Amino-1,4-dihydro-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
- 5-Amino-1,6-dihydro-7H-v-triazolo(4,5-d)pyrimidin-7-one
- 5-Amino-1H-triazolo(4,5-d)pyrimidin-7-ol
- 5-Amino-1H-v-triazolo(d)pyrimidin-7-ol
- 5-Amino-1H-(1,2,3)Triazolo(4,5-d)pyrimidin-7-ol
- 5-Amino-7-hydroxy-1H-v-triazolo(d)pyrimidine
- 7H-1,2,3-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-1,4-dihydro- (9CI)
- 7H-1,2,3-Triazolo(4,5-d)pyrimidinone, 5-amino-1,4-dihydro-
- 7H-v-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-1,6-dihydro-
- 8 AG
- 8azaG
- Azaguanine
- Azaguanine-8
- Azan
- AZG
- B-28
- Guanazol
- Guanazolo
- NSC-749
- Pathocidin
- Pathocidine
- SF-337
- SK 1150
- Triazologuanine
- v-Triazolo(4,5-d)pyrimidin-7-ol,5-amino-
References
- Tong, George L.. Lee, William W.. Goodman, Leon. Frederiksen, Sune. Synthesis of some 2′-deoxyribosides of 8-azaadenine. 1965. Archives of Biochemistry and Biophysics. 112. 1. Elsevier. University of California. 76. 10.1016/0003-9861(65)90012-3.
- Colsky, J.. Meiselas, E.L.. Rosen, J.S.. Schulman, I.. 1955. Response of patients with leukemia to 8-azaguanine. Blood. 10. 5. 482–92. 14363328. 10.1182/blood.V10.5.482.482. free.
- Chemotherapy of Cancer: the Antimetabolite Approach. Timmis. G.M.. Williams. Donald Charles. Butterworths. 1967. University of Michigan. 36.
- Web site: MSDS 7H-v-Triazolo(4,5-d)pyrimidin-7-one,5-amino-1,6-dihydro- CAS 134-58-7 MSDS * 8 AG * 5-Amino-1,6-dihydro-7H-v-triazolo(4,5-d)pyrimidin-7-one * 5-Amino-1,4-dihydro-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one * 5-Amino-7-hydroxy-1H-v-triazolo(d)pyrimidine * 5-Amino-1H-v-triazolo(d)pyrimidin-7-ol * Azaguanine * Azaguanine-8 * 8-Azaguanine * Azan * AZG * B-28 * Guanazol * Guanazolo * NSC-749 * Pathocidin * Pathocidine * SF-337 * SK 1150 * Triazologuanine * v-Triazolo(4,5-d)pyrimidin-7-ol, 5-amino- * 7H-1,2,3-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-1,4-dihydro- . www.chemcas.com . 2009-03-03.
- Web site: Azaguanine - Compound Summary (Synonyms). 27 March 2005. National Center for Biotechnology Information. 2009-03-03.
External links
