8,11-Dihydroxytetrahydrocannabinol Explained

8,11-Dihydroxytetrahydrocannabinol (8β,11-diOH-Δ⁹-THC) is an active metabolite of THC, the main active component of cannabis. The 8β enantiomer retains psychoactive effects in animal studies with only slightly lower potency than THC, while the 8α enantiomer is much weaker. Both enantiomers have a shorter half-life in the body than 11-hydroxy-THC, making 8,11-dihydroxy-THC potentially useful for drug testing to distinguish between recent cannabis use and use longer in the past.^{[1] [2] [3]}

See also

• 3'-Hydroxy-THC
• 7-Hydroxycannabidiol
• 11-Hydroxy-Delta-8-THC
• 11-Nor-9-carboxy-THC
• Cannabitriol
• Cannabiripsol

Notes and References

1. Pitt CG, Fowler MS, Sathe S, Srivastava SC, Williams DL . Synthesis of metabolites of delta-9-tetrahydrocannabinol . Journal of the American Chemical Society . 97 . 13 . 3798–3802 . June 1975 . 1141589 . 10.1021/ja00846a040 .
2. Book: Järbe TU, Mathis DA . Discriminative stimulus functions of cannabinoids/cannabimimetics . Drug Discrimination: Applications to Drug Abuse Research . NIDA Research Monograph . 116 . 75–99 . 1991 . 1369683 .
3. Gasse A, Pfeiffer H, Köhler H, Schürenkamp J . 8β-OH-THC and 8β,11-diOH-THC-minor metabolites with major informative value? . International Journal of Legal Medicine . 132 . 1 . 157–164 . January 2018 . 28983686 . 10.1007/s00414-017-1692-5 . 19208736 .