7beta-hydroxysteroid dehydrogenase (NADP+) explained
| 7-beta-hydroxysteroid dehydrogenase (NADP+) |
| Ec Number: | 1.1.1.201 |
| Cas Number: | 79393-83-2 |
| Go Code: | 0047022 |
| 7-beta-hydroxysteroid dehydrogenase |
In enzymology, a 7beta-hydroxysteroid dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction
a 7beta-hydroxysteroid + NADP+
a 7-oxosteroid + NADPH + H
+Thus, the two substrates of this enzyme are 7beta-hydroxysteroid and NADP+, whereas its 3 products are 7-oxosteroid, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7beta-hydroxysteroid:NADP+ 7-oxidoreductase. Other names in common use include NADP+-dependent 7beta-hydroxysteroid dehydrogenase, and 7beta-hydroxysteroid dehydrogenase (NADP+).
References
- Savino S, Ferrandi EE, Forneris F, Rovida S, Riva S, Monti D, Mattevi A . Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity . Proteins . 84 . 6 . 859–65 . June 2016 . 27006087 . 10.1002/prot.25036 . 36310113 .
- Hirano S, Masuda N . Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens . Applied and Environmental Microbiology . 43 . 5 . 1057–63 . May 1982 . 10.1128/AEM.43.5.1057-1063.1982 . 6954878 . 244185 . 1982ApEnM..43.1057H .
- MacDonald IA, Roach PD . Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum . Biochimica et Biophysica Acta . 665 . 2 . 262–9 . August 1981 . 6945134 . 10.1016/0005-2760(81)90011-4 .
- MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV . Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms . Applied and Environmental Microbiology . 44 . 5 . 1187–95 . November 1982 . 10.1128/AEM.44.5.1187-1195.1982 . 6758698 . 242167 . 1982ApEnM..44.1187M .
